Showing posts with label Genetics. Show all posts
Showing posts with label Genetics. Show all posts

Saturday, August 21, 2010

X-chromosome Inactivation & Dosage Compensation

Dosage Compensation

  • A phenomenon of neutralization of differences in sex-linked gene doses, i.e. males with one X-chromosome and females with two X-chromosomes have identical X-linked gene products
  • First report of this phenomenon → Muller (1931) while working with the wa allele observed that there is a mechanism compensating for the difference in the dosage of X-linked gene between the sexes